mass spectrometry machinery in a lab

The UA Mass Spectrometry Facility is hosted in the Department of Chemistry & Biochemistry. The facility currently has six mass spectrometers. Typical types of analysis are listed. For molecules with molecular masses below about 2 kDa, characterization can include structural information obtained from fragmentation, as well as determination of molecular mass and chemical formula using high resolution. All ESI and MALDI experiments can be performed with positive or negative ions.

  • Volatile organic compound characterization and quantitation: EI MS, GC-MS, GC-MS/MS
  • Inorganic compound characterization: ESI infusion MS & MS/MS, MALDI MS & MS/MS
  • Small molecule polar compound (e.g. pharmaceuticals, metabolites) characterization and quantitation: ESI infusion MS & MS/MS, LC-MS/MS, UPLC-MS , UPLC-MRM
  • Protein characterization: ESI infusion MS, MALDI MS; peptide mapping: MALDI MS & MS/MS, LC-MS/MS, UPLC-MS
  • Peptide sequencing: MS/MS with ESI or MALDI using CID, ETD, or ISD in positive and negative ion modes
  • Carbohydrate characterization: ESI infusion MS & MS/MS, MALDI MS & MS/MS, LC-MS/MS
  • Oligonucleotide characterization: ESI infusion MS & MS/MS , MALDI MS & MS/MS, LC-MS/MS
  • Polymer characterization, including determination of average molecular weights: ESI infusion MS & MS/MS, MALDI MS & MS/MS
  • MALDI imaging: image (location) analysis of a wide range of compounds (e.g. lipids, proteins, carbohydrates, pharmaceuticals, metabolites, polymers, inorganic) from various substrates (e.g. animal or plant tissue slices, polymeric or inorganic material surfaces)

For additional information on instrumentation, services, sample submission, fees, and training, see the links at the top of this page.  The Facility Manager, Dr. Qiaoli Liang, can also be contacted for further information.

Lab Location: Shelby 1074, 1082, 1084.

Address: 250 Hackberry Lane, Tuscaloosa, AL 35401